Researchers developed AI tools to detect aging signatures in routine tissue samples, offering a new way to monitor biological age and disease progression across different organs.

Physical activity preserves ovarian function in aging mice by activating adiponectin-related pathways, offering mechanistic insight into how exercise may extend reproductive lifespan.

Blood test measuring p-tau217 shows excellent diagnostic accuracy for Alzheimer's both cross-sectionally and over time, potentially enabling earlier detection without brain scans or spinal taps.

When mitochondria falter, worms activate a lysosomal quality-control pathway controlled by the ELT-2 transcription factor, boosting cellular recycling and extending lifespan—a potentially conserved longevity mechanism.

Skin cells from naked mole-rats—exceptionally long-lived rodents—undergo reversible vacuolation when lysosomes are stressed, suggesting unique cellular stress management that may contribute to their longevity.

Comprehensive review examines mechanisms and strategies for regenerating the thymus, the master gland of immunity that atrophies with age, offering potential paths to restore youthful immune function.

High-resolution imaging combined with proteomic analysis of over 7,000 proteins reveals novel molecular signatures associated with bone loss at the radius and tibia in aging men.

Researchers found that TIMP2, a protein abundant in young blood, controls microglial state and function in both healthy and aged mouse brains, suggesting a mechanism for age-related cognitive decline.

A randomized controlled trial found that CBT for insomnia reduced biological age by nearly a year compared to controls, as measured by DNA methylation clocks in older adults.

Meloxicam, an FDA-approved NSAID, prevented muscle wasting and metabolic decline in aging mice by restoring Cdon protein levels and reducing oxidative stress, suggesting repurposing potential.

Higher levels of TMAO, a gut microbiome metabolite, correlate with age, cardiometabolic risk factors, and degenerative brain changes in healthy older adults.

Microglia and perivascular macrophages undergo extensive functional changes during aging and neurodegeneration, revealing new therapeutic targets for Alzheimer's disease.

Aging microglia with shortened telomeres secrete DLK1, triggering myelin loss and neuronal dysfunction—a potential new target to prevent age-related cognitive decline.

Researchers identified a mechanism keeping bone marrow adipocytes young that supports stem cell-based bone regeneration. The finding may explain age-related decline in bone healing and suggest new therapeutic targets.

A new review in Aging journal explores metformin's potential as a longevity intervention, synthesizing evidence on how this diabetes drug may influence fundamental aging processes.

Blocking the histone demethylase KDM4C enhances natural killer cell killing of TP53-mutant leukemia cells by activating the cGAS-STING immune pathway, suggesting a new therapeutic strategy.

Specific epigenetic signatures in skeletal muscle tissue correlate with physical performance metrics in healthy aging, suggesting DNA methylation may serve as a biomarker for functional decline.

Mosaic loss of the Y chromosome in blood cells—a common age-related phenomenon in men—associates with increased risk of cardiovascular diseases affecting arteries and the aorta.

Suppressing the pro-inflammatory signals from senescent cells immediately after radiotherapy prevents long-term bone deterioration, suggesting a critical early intervention window.

Longitudinal imaging study identifies distinct clusters of healthy older adults with varying rates of cortical thinning, suggesting brain aging is not uniform across individuals.